Transient Protein Expression Market is expected to reach US$ 1,320.38 Million by 2031

Instruments Held Largest Share in Transient Protein Expression Market in 2023

According to our new research study on "Transient Protein Expression Market Forecast to 2031 – Global Analysis – by Product Type, Application, and End User," the market is expected to grow from US$ 836.68 million in 2023 to US$ 1,320.38 million by 2031; it is anticipated to record a CAGR of 5.9% from 2023 to 2031. The market report emphasizes trends prevalent in the global market, along with drivers and deterrents affecting its growth. The increasing applications of protein expression systems and the surging popularity of precision medicine are among the prominent factors driving the market growth. However, the high cost of products hampers the growth of the market. The integration of artificial intelligence (AI) and automation technologies is expected to bring new transient protein expression market trends in the coming years.

Increasing Applications of Protein Expression Systems Propels Transient Protein Expression Market Growth

Animal and plant cell-based transient protein expression systems have been in use for the last three decades. Significant advancements in proteomics in recent years have resulted in the availability of newer recombinant protein varieties. The practicality and reproducibility of transient protein expression in animal and plant cells encourage research and development activities to extend their applications in human cell lines. Many contract research and development organizations as well as biopharmaceutical companies, among others, have focused their efforts on incorporating transient protein expression into their production processes. This type of expression system allows them to use different genes to create recombinant proteins without relying on the development of stable cell lines.

Transient Protein Expression Market, by Region, 2023 (%)

Source: The Insight Partners Analysis

The temporary protein expression process finds widespread application in the manufacturing of growth factors, cytokines, hormones, blood products, modified human proteins, and monoclonal antibodies. Moreover, the creation and use of effective bioprocessing techniques have become essential for the commercial synthesis of recombinant proteins with a significant therapeutic value. Recent developments in the field of bioprocessing are being applied to provide efficient methods for generating recombinant proteins. Modern Quality by Design concepts, continuous upstream processing, continuous chromatography, integrated continuous bioprocessing, high-throughput devices for efficient bioprocess optimization, disposable systems, and process analytics technologies for higher yields of high-quality products are among the recent developments.

Transient protein expression platforms are increasingly being used in vaccine development applications since the onset of the COVID-19 pandemic. Various researchers began studying the SARS-CoV-2 and its variants extensively by using transient protein expression systems. For instance, in March–April 2020, Absolute Antibody (UK) scaled up the production of multigram quantities of different anti-SARS-CoV-2 spike proteins to aid in the development of neutralizing antibodies. Similarly, transient protein expression systems were widely used to produce positive control proteins as a part of the in-vitro diagnostics kits development processes. Thus, the increasing applications of protein expression systems fuel the transient protein expression market growth.

The transient protein expression market analysis has been carried out by considering the following segments: product type, application, end user, and geography. The market, by product type, is segmented into instruments, reagents, expression vectors, and competent cells. The instruments segment held the largest transient protein expression market share in 2023. Standardized Instruments used in transient protein expression are categorized as automated transient protein expression systems and manual transient protein expression systems. The choice of instrument depends on the kind of protein, the requirements for functional activity, and the expected levels of yield.

The transient protein expression market, by application, is segmented into genomic research, gene therapy, bioproduction, cancer research, and drug development. The genomic research segment held a larger share of the market in 2023. Large-scale transient gene expression (TGE) is a technology that is deemed suitable for producing recombinant therapeutic proteins. TGE involves producing a recombinant protein over 1–14 days following the transfer of DNA into single-cell suspension cultures. A recombinant gene is typically cloned in a nonviral expression vector and then transfected into cells using a chemical delivery agent such as calcium phosphate (CaPi).

The transient protein expression market, by end user, is classified into pharmaceutical and biotechnology companies, academic and research institutes, and clinical research organizations. The pharmaceutical and biotechnology companies segment held the largest share of the market in 2023.

The transient protein expression market, by application, is bifurcated into in vitro diagnostics and electrolyte analysis. The in vitro diagnostics segment held a larger share of the market in 2023. Recent advancements in plant-based (stable and transient) therapeutic protein expression, along with a shift in focus toward the commercial production of vaccines, antibodies, and biopharmaceuticals, leads to maximum use of therapeutic protein expression systems in pharmaceutical and biotechnology companies. Besides, pharmaceutical and biotechnology firms are increasing their spending on research and R&D activities.

The geographic scope of transient protein expression market report entails North America (US, Canada, and Mexico), Europe (Spain, UK, Germany, France, Italy, and Rest of Europe), Asia Pacific (South Korea, China, India, Japan, Australia, and Rest of Asia Pacific), the Middle East & Africa (South Africa, Saudi Arabia, UAE, and Rest of Middle East & Africa), and South & Central America (Brazil, Argentina, and Rest of South & Central America). In terms of revenue, North America accounted for the largest transient protein expression market share in 2023. The US is the world's most important market for transient protein expression procedures and systems. The market growth in the country is attributed to extensive research and development activities in the biopharmaceuticals industry, a growing number of startups involved in protein expression, and the rising adoption of recombinant protein for therapeutic applications. In addition, the presence of various market leaders operating in the US contributes notably to the expansion of the transient protein expression market size.

Competitive Landscape

Thermo Fisher Scientific, Promega Corporation, Merck KGAA, Takara Bio Inc, Qiagen, Bio-Rad Laboratories, Inc., New England Biolabs, Genscript Biotech Corporation, Agilent, Lonza, Mirus Bio LLC, and MaxCyte Inc are among the leading companies profiled in the transient protein expression market report. These companies implement both organic (product launches, expansions, product approvals, etc.) and inorganic (collaborations, partnerships, and so on) strategies to stay competitive in the market. 

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