Microelectrode Array in Vitro Market is expected to reach US$ 25.67 Million by 2031

Multiwell-MEA Segment to Bolster Microelectrode Array in Vitro Market Growth During 2023–2031

According to our new research study on "Microelectrode Array in Vitro Market Forecast to 2031 – Global Analysis – by Product and Application" the market is expected to reach US$ 25.67 million by 2031 from US$ 17.96 million in 2023; it is estimated to record a CAGR of 4.6% during 2023–2031. The microelectrode array in vitro market report emphasizes the trends prevalent in the global market, along with drivers and deterrents affecting its growth.

Increasing demand for microelectrode arrays in neuroscience research and a rising focus on developing alternatives for animal testing models are contributing to the microelectrode array in vitro market growth. However, the high development costs of microelectrode arrays hamper the market growth. Nevertheless, the integration of microelectrode array technologies with organ-on-a-chip is expected to bring new microelectrode array in vitro market trends in the coming years. 

Microelectrode Array in Vitro Market  Share, by Region, 2023 (%)

Increasing Demand for Microelectrode Arrays in Neuroscience Research Bolsters Microelectrode Array in Vitro Market

Neuroscience research involves testing new drugs on neuronal cultures to evaluate their effects on neural activity and develop targeted treatments. Researchers utilize in vitro models to investigate a variety of neurological and neuropsychiatric diseases, including Alzheimer's disease, Parkinson's disease, and epilepsy, as well as various neurodevelopmental disorders. The increasing prevalence of such neurological disorders increases the demand for microelectrode array systems in neuroscience research. Microelectrode arrays in vitro allow for the examination of specific cellular and molecular changes related to neurological conditions and their effects on neural functions. By measuring neural activity in in vitro cell models using microelectrode arrays, researchers can assess drug compounds' ability to modulate neural activity, restore normal network function, or counteract disease-related abnormalities. This information is essential for identifying promising drug candidates at an early stage of drug development. With the growing utilization of microelectrode arrays in neuroscience research laboratories, market players such as Axion BioSystems, Multi Channel Systems, and MaxWell Biosystems are adopting strategies to launch innovative products in the market. For instance, in April 2024, Axion BioSystems launched the Maestro Volt, an affordable benchtop microelectrode array system tailored for academic labs with lower throughput needs. This 6-well device, suitable for neurological and cardiovascular research, offers user-friendly features and high-quality controls associated with the company’s Maestro brand. Therefore, a surge in neuroscience research for developing new drugs for neurodegenerative diseases boosts the demand for microelectrode arrays in vitro, which drives the market.

The microelectrode array in vitro market analysis has been carried out by considering the following segments: product, application, and geography. The microelectrode array in vitro market, based on product, is segmented into classical MEA, multiwell-MEA, and CMOS-MEA. The multiwell-MEA segment held the largest microelectrode array in vitro market share in 2023, and it is expected to register the highest CAGR during 2023–2031. Multiwell microelectrode arrays are sophisticated experimental platforms comprising a matrix of small electrodes embedded in a substrate, usually organized into multiple wells. The "multiwell" feature of the microelectrode array system refers to its design, which includes multiple distinct wells or chambers similar to those found in standard tissue culture plates. Each well in the array typically contains a biological sample, such as neurons, cardiac cells, or other excitable tissues, and is equipped with multiple electrodes capable of recording electrical signals from these cells or tissues. This design allows researchers to simultaneously investigate different conditions, treatments, or experimental variations. The multiwell format enables high-throughput experiments where multiple conditions or compounds can be tested simultaneously. Their capability to monitor large-scale networks of cells in real time makes them invaluable in fields such as neuroscience, cardiology, toxicology, and stem cell research. This technology helps with the understanding of cellular dynamics, disease mechanisms, and potential therapeutic interventions. A few of the commercially available microelectrode arrays include the Axion Maestro multiwell microelectrode array platform by Axion Biosystems, the MaxTwo High-Density Microelectrode Array System by MaxWell Biosystems, and the Multiwell-MEA System manufactured by Multi Channel Systems MCS GmbH. The Axion Maestro microelectrode array platforms, including the Maestro Pro Maestro Edge multiwell microelectrode array, offer researchers an easy-to-use benchtop assay for analyzing neural and cardiomyocyte network signaling.

The market, based on application, is segmented into cardiomyocytes, nerve, and others. The cardiomyocytes segment held the largest microelectrode array in vitro market share in 2023. Cardiomyocytes are the cells responsible for the contraction and relaxation of the heart. These cells can be derived from human induced pluripotent stem cells that yield high purity. Mature cardiomyocytes have the potential to replace damaged or dysfunctional cardiac tissue and can also be used for screening cardiac drugs and toxins. Using microelectrode arrays, researchers can monitor the electrophysiological responses of cardiomyocytes to different compounds, aiding in the early identification of potential cardiac side effects during drug development. Human pluripotent stem cell-derived cardiomyocytes are an appealing model for researching inherited and drug-induced arrhythmias. These disorders often arise from subtle alterations in electrophysiological properties such as cardiomyocyte excitability, contractility, or both. Microelectrode arrays serve as an important tool for studying the electrophysiological properties of these cells.

The Maestro line of microelectrode arrays offered by Axion Biosystems records functional cell information in cardiac research fields such as cardiotoxicity, stem cell-derived cardiomyocyte development, and excitation-contraction coupling.

The geographic scope of the microelectrode array in vitro market report includes the assessment of the market performance in North America, Europe, Asia Pacific, Middle East and Africa, South and Central America. North America accounted for the largest microelectrode array in vitro market size in 2023. The presence of major market players, early adoption of technologically advanced products, and collaborations between government institutions and industry players are the key factors fueling the market growth. The growing adoption of microelectrode arrays in vitro models such as organoids has led to the development of innovative technologies, including 3D microelectrode array technology and CMOS-based high-density microelectrode array technology. For instance, in January 2023, BMSEED, a US-based provider of microelectrode array technologies, filed a non-provisional patent application for the advancement of its 2D stretchable microelectrode array (sMEA) into the third dimension, creating the 3D-sMEA. This technology allows electrophysiological measurements from brain organoids and 3D tissue cultures, particularly focused on Alzheimer's disease. The 3D-sMEA features adjustable pockets with embedded electrodes that conform to organoids, enabling researchers to record neural signals from ~80% of the surface area of intact organoids. Thus, the higher rate of early adoption of emerging microelectrode array technologies and the rising research in the fields of neuroscience, cardiology, and toxicology for creating new therapies for neurological and cardiovascular diseases are likely to increase the demand for microelectrode array in vitro solutions across the US in the near future.

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